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KalVista Pharmaceuticals develops novel therapies for hereditary angioedema, targeting unmet medical needs with oral medications.
KalVista Pharmaceuticals is a clinical stage pharmaceutical company dedicated to discovering and developing drug therapies for diseases with significant unmet medical needs. Their primary focus is on hereditary angioedema (HAE), where they have developed a novel oral therapy called sebetralstat, which targets plasma kallikrein, a key mediator of inflammation in HAE. In June 2024, they submitted a New Drug Application to the FDA for sebetralstat, which aims to provide patients with a more convenient oral treatment option for this debilitating condition, moving away from the less convenient injectable therapies currently available.
In addition to sebetralstat, KalVista is exploring other inhibitors with novel oral therapies, including a Factor XIIa inhibitor in preclinical development. With a strong interest in enhancing the quality of life for patients suffering from HAE, KalVista is strategically focused on leveraging their scientific expertise and expanding into global markets. Their planned submissions for regulatory approvals in Europe and Japan highlight their commitment to broadening access to their innovative therapies.
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