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Syros Pharmaceuticals develops targeted therapies for hematologic cancers, focusing on unmet needs in HR-MDS and AML.
Syros Pharmaceuticals is a biopharmaceutical company focused on developing advanced therapies for hematologic malignancies, specifically targeting blood disorders like higher-risk myelodysplastic syndrome (HR-MDS) and acute myeloid leukemia (AML). The company's primary candidate, tamibarotene, is a selective retinoic acid receptor alpha (RARĪ±) agonist. They are currently conducting Phase 3 and Phase 2 clinical trials to evaluate the efficacy of tamibarotene in combination with established treatments, azacitidine and venetoclax, respectively, for patient populations with overexpression of the RARA gene. The FDA has granted Fast Track Designation to tamibarotene, emphasizing its potential as a significant treatment option for patients who are not suitable for intensive chemotherapy.
In addition to tamibarotene, Syros holds the rights to other investigational products, particularly SY-2101 and SY-5609. The company aims to utilize strategic marketing and a specialized sales force to penetrate the markets for HR-MDS and unfit AML therapies once regulatory approval is obtained. By focusing on a well-defined target population with significant unmet medical need and laying out plans to engage healthcare providers with tailored marketing strategies, Syros looks to establish itself as a leader in innovative treatments for blood cancers.
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